ADVANCING INNOVATION
Thoughtfully Approaching GI Drug Discovery
Ironwood Pharmaceuticals’ commitment to redefining the standard of care for patients suffering from GI diseases and disorders is unwavering. We understand that debilitating GI diseases exist, and countless patients need meaningful and effective medicines.
We are focused on following the science and strengthening our portfolio by pursuing opportunities in organic GI diseases with significant unmet medical need, strong mechanistic rationale, and commercial viability. By following this strategy, we can leverage our leading GI capabilities and expertise now and in the future.
Strengthening Our Leading GI Portfolio
Apraglutide
In June 2023, we expanded our pipeline through the acquisition of VectivBio to include apraglutide, an investigational GLP-2 analog being evaluated as a potential once-weekly treatment for patients with Short Bowel Syndrome with intestinal failure (SBS-IF).
SBS-IF is a severe malabsorptive condition requiring ongoing I.V. administration of fluids and nutrients and is associated with significant morbidity and mortality, high economic burden, and an impaired quality of life. A substantial number of SBS-IF patients remain dependent on chronic parenteral support, and there is considerable unmet need in this patient population, which has an estimated addressable population of 18,000 adult patients across the U.S., Europe, and Japan
